{"id":25,"date":"2024-02-21T14:33:14","date_gmt":"2024-02-21T14:33:14","guid":{"rendered":"http:\/\/www.dokubiyoteknoloji.com\/?page_id=25"},"modified":"2024-02-29T09:47:41","modified_gmt":"2024-02-29T09:47:41","slug":"fibrocell","status":"publish","type":"page","link":"https:\/\/www.dokubiyoteknoloji.com\/?page_id=25","title":{"rendered":"Fibrocell\u00ae"},"content":{"rendered":"\t\t
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Otolog Fibroblast H\u00fccre Tedavisi\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tFIBROCELL\u00ae, ki\u015finin kendi dokusundan elde edilen fibroblast h\u00fccrelerinin, y\u00fcksek teknolojiye sahip laboratuvar ortam\u0131nda, biyom\u00fchendislik teknikleri ile \u00e7o\u011falt\u0131larak ki\u015finin ihtiya\u00e7 duydu\u011fu b\u00f6lgeye enjekte edilmesine dayanan otolog bir tedavi y\u00f6ntemidir.

\nFIBROCELL\u00ae, kollajen, elastin ve hyal\u00fcronik asit gibi derinin yap\u0131ta\u015f\u0131 proteinlerini en saf ve do\u011fal \u015fekilde \u00fcreten ki\u015finin kendi fibroblast h\u00fccrelerinden olu\u015fur.\nFIBROCELL\u00ae, gerek kronik yara tedavisinde doku b\u00fct\u00fcnl\u00fc\u011f\u00fcn\u00fcn yeniden sa\u011flanmas\u0131na gerekse daha \u00e7ok medyada bilinen y\u00f6n\u00fcyle ya\u015flanmaya ba\u011fl\u0131 ciltteki derin \u00e7izgilerin giderilmesine destek olmada, ki\u015fiye \u00f6zel olarak \u00fcretilmektedir. Otolog fibroblast uygulamas\u0131, FDA taraf\u0131ndan onay alm\u0131\u015f ilk otolog h\u00fccresel tedavi y\u00f6ntemidir.\n

\n*FIBROCELL\u00ae, DOKU B\u0130YOTEKNOLOJ\u0130 LTD.\u015eT\u0130.\u2019ye ait olup, T\u00fcrkiye\u2019deki ilk tescilli otolog fibroblast h\u00fccre \u00fcr\u00fcn\u00fcd\u00fcr.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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3 ad\u0131mda ALLOBLAST\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Hekim, lokal anestezi alt\u0131nda, tercihen kulak arkas\u0131ndan mercimek b\u00fcy\u00fckl\u00fc\u011f\u00fcnde 1-2 adet biyopsi al\u0131r. Kan numuneleri ile biyopsi \u00f6rne\u011fi, FIBROCELL\u00ae so\u011fuk zincir ta\u015f\u0131ma \u00e7antas\u0131na konularak, 2 \u2013 8 \u00b0C\u2019de DOKU laboratuvar\u0131na ula\u015ft\u0131r\u0131l\u0131r.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tOTOLOG FIBROCELL\u00ae \u00dcRET\u0130M\u0130<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t

Y\u00fcksek teknoloji sistemine sahip GMP onayl\u0131 s\u0131f\u0131r partik\u00fcl laboratuvarda, milyonlarca yeni fibroblast h\u00fccresinin \u00e7o\u011falmas\u0131 sa\u011flan\u0131r. Bu i\u015flem otolog fibroblast \u00fcretim tekni\u011fine \u00f6zg\u00fc kiritik prosesler dahilinde ger\u00e7ekle\u015ftirilir. \u00dcretilen fibroblast h\u00fccreleri Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131\u2019n\u0131n ve Avrupa Standart\u0131\u2019n\u0131n belirlemi\u015f oldu\u011fu kalite kontrol s\u00fcre\u00e7lerinden ge\u00e7erek uygulamaya haz\u0131r hale gelir.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t<\/path><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tFIBROCELL\u00ae UYGULAMA<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t

Ki\u015fi klini\u011fe gelir; topikal anestezik kremler ile cilt uyu\u015fturulur. FIBROCELL\u00ae ki\u015finin istenile b\u00f6lgesine enjekte edilir. FIBROCELL\u00ae uygulamas\u0131 3 seanstan olu\u015fmaktad\u0131r. \u0130lk seans yakla\u015f\u0131k biyopsi al\u0131m\u0131ndan 4-6 hafta sonras\u0131nda haz\u0131r olur; 2. ve 3. seanslar ise 2-3 hafta ara ile ger\u00e7ekle\u015ftirilebilmektedir. FIBROCELL\u2019in etkisi 2. ay itibariyle ba\u015flar ve artarak devam eder*. Yap\u0131lan \u00e7al\u0131\u015fmalarda 5 y\u0131la kadar etkinli\u011fin devam etti\u011fi g\u00f6sterilmi\u015ftir1<\/sup><\/p>

*Doktor ve uygulama yapt\u0131ran 500+ ki\u015finin geri bildirimleri do\u011frultusunda ifade edilmi\u015ftir.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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FIBROCELL\u00ae Avantajlar\u0131\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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  • Ki\u015fiye \u00f6zel \u00fcretilir, dolay\u0131s\u0131yla alerji riski minimumdur.<\/li>
  • FDA taraf\u0131ndan onaylanm\u0131\u015f h\u00fccresel bir tedavi y\u00f6ntemidir.<\/li>
  • Uzun etkilidir.<\/li>
  • Hayvansal hastal\u0131k olu\u015fturma riski yoktur.<\/li>
  • Yeterince elastiktir.<\/li>
  • Botox ya da bir dolgu malzemesi bile\u015fenlerini i\u00e7ermez, saf h\u00fccre sol\u00fcsyonudur.<\/li>
  • Mimiklerde veya y\u00fcz ifadesinde de\u011fi\u015fikli\u011fi sebep olabilecek bir g\u00f6r\u00fcn\u00fcm olu\u015fturmaz.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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    ALLOBLAST \u00ae Uygulamas\u0131n\u0131n Kullan\u0131m Alanlar\u0131<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    • Ciltteki k\u0131r\u0131\u015f\u0131kl\u0131klar\u0131n giderilmesine,<\/li>
    • Lekelerin ve koyu alanlar\u0131n renginin a\u00e7\u0131lmas\u0131na,<\/li>
    • Kapanmayan kronik yaralar\u0131n (diyabet, bas\u0131, ven\u00f6z \u00fclser vb.) kapanmas\u0131na,<\/li>
    • Mezoterapi ile yap\u0131labilecek y\u00fcz yenileme (Facial rejuvenation) uygulamalar\u0131na,<\/li>
    • Akne veya su\u00e7i\u00e7e\u011fi gibi rahats\u0131zl\u0131klar sonras\u0131 olu\u015fan \u00e7ukurlar\u0131n doldurulmas\u0131na,<\/li>
    • Yan\u0131k, ge\u00e7irilmi\u015f cerrahi ya da travmaya ba\u011fl\u0131 oyukluk ve nedbelerin tedavisine,<\/li>
    • Dudaklar\u0131n dolgunla\u015ft\u0131r\u0131lmas\u0131na,<\/li>
    • Kellik olgular\u0131nda indirekt olarak ve<\/li>
    • Di\u015f hekimli\u011finde di\u015f eti \u00e7ekilmesinin \u00f6nlenmesine destek olmada kullan\u0131labildi\u011fine dair bilimsel veya klinik \u00e7al\u0131\u015fmalar mevcuttur.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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      FIBROCELL uygulamas\u0131, temel olarak kollajen ve elastin ba\u015fta olmak \u00fczere dermal rejenerasyonda etkili oldu\u011fu bilinen ekstrasel\u00fcler matriks proteinleini \u00fcreten fibroblastlar\u0131n cilde yerle\u015ftirilerek birim alandaki konsantrasyonun artt\u0131r\u0131lmas\u0131d\u0131r. Ancak, ki\u015finin durumu, ya\u015f\u0131, genetik yatk\u0131nl\u0131klar\u0131, ya\u015fam \u015fekli, g\u0131da t\u00fcketim al\u0131\u015fkanl\u0131klar\u0131 ve bir\u00e7ok fakt\u00f6r\u00fcn daha, bu uygulamadan al\u0131nacak ba\u015far\u0131y\u0131 etkileyece\u011fi bilinmeli ve mutlak suretle doktor de\u011ferlendirmesi neticesinde uygulama karar\u0131 verilmelidir.<\/span><\/p>

      Web sitesinde yer alan bilgilerin tamam\u0131 bilgilendirme ama\u00e7l\u0131d\u0131r. A\u00e7\u0131klamalara ek olarak bilimsel ve klinik \u00e7al\u0131\u015fmalar\u0131n yer ald\u0131\u011f\u0131 referans listesi sayfalarda yer al\u0131r. Herhangi bir \u00fcr\u00fcn veya \u00fcr\u00fcnlerin kullan\u0131m\u0131na, h\u00fccresel uygulamay\u0131 yapt\u0131rmak isteyen ki\u015fi ve uygulamay\u0131 ger\u00e7ekle\u015ftirecek doktor taraf\u0131ndan karar verilir.<\/p>

      Doku Biyoteknoloji K\u00f6k H\u00fccre, Biyobanka ve Doku M\u00fchendisli\u011fi Merkezi, Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131 nezdinde yetkilendirilmi\u015f ve bu kapsamda izin belgelerine haiz bir tesis olarak, h\u00fccresel \u00fcr\u00fcnleri ulusal\/uluslararas\u0131 normlara ve GMP gerekliliklerine uygun olarak \u00fcretmek, kalite analizlerini yapmak, depolamak ve al\u0131c\u0131s\u0131 i\u00e7in uygulama yapmak \u00fczere talep ve onam ileten doktora h\u00fccresel \u00fcr\u00fcn\u00fc teslim etmekle y\u00fck\u00fcml\u00fcd\u00fcr. Uygulama i\u015flemi; doktor taraf\u0131ndan uygun klinik \u015fartlarda, D\u00fcnya\u2019daki bilimsel ve klinik verilere dayal\u0131 endikasyona uygun teknik ve s\u00fcre ile, kanun ve mesleki etik kurallar \u00e7er\u00e7evesinde ger\u00e7ekle\u015ftirilmek zorundad\u0131r. Bu noktada sorumluluk; ba\u015fta uygulama yap\u0131lan ki\u015fi olmak \u00fczere, sonras\u0131nda uygulay\u0131c\u0131 hekim ve\/veya uygulama merkezi yetkilisi ile yerel denetleyici sa\u011fl\u0131k otoritesindedir.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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      Bilimsel \u00c7al\u0131\u015fmalar\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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      1. Mehrabani D, Manafi N. Role of Cultured Skin Fibroblasts in Aesthetic and Plastic Surgery. World J Plast Surg. 2013;2(1): 2-5.<\/li>
      2. Weiss, R.A. Autologous cell therapy: Will it replace dermal fillers? Fac. Plast. Surg. Clin.N. Am. 2013, 21, 299\u2013304.<\/li>
      3. Morimoto, N.; Saso, Y.; Tomihata, K.; Taira, T.; Takahashi, Y.; Ohta, M.; Suzuki, S. Viability and function of autologous and allogeneic fibroblasts seeded in dermal substitutes after implantation. J. Surg. Res. 2005, 125, 56\u201367.<\/li>
      4. Smith, S.R.; Munavalli, G.; Weiss, R.; Maslowski, J.M.; Hennegan, K.P.; Novak, J.M.A multicenter, double-blind, placebo-controlled trial of autologous fibroblast therapy for the treatment of nasolabial fold wrinkles. Dermatol. Surg. 2012, 38, 1234\u20131243.<\/li>
      5. Wisser, D.; Steffes, J. Skin replacement with a collagen based dermal substitute, autologous keratinocytes and fibroblasts in burn trauma. Burns 2003, 29, 375\u2013380.<\/li>
      6. Boss, W.K., Jr.; Usal, H.; Fodor, P.B.; Chernoff, G. Autologous cultured fibroblasts: A protein repair system. Ann. Plast. Surg. 2000, 44, 536\u2013542.<\/li>
      7. Watson, D.; Keller, G.S.; Lacombe, V.; Fodor, P.B.; Rawnsley, J.; Lask, G.P. Autologous fibroblasts for treatment of facial rhytids and dermal depressions. A pilot study. Arch. Fac. Plast. Surg. 1999, 1, 165\u2013170.<\/li>
      8. Weiss, R.A.; Weiss, M.A.; Beasley, K.L.; Munavalli, G. Autologous cultured fibroblast injection for facial contour deformities: A prospective, placebo-controlled, Phase III clinical trial.Dermatol. Surg. 2007, 33, 263\u2013268.<\/li>
      9. Munavalli, G.S.; Smith, S.; Maslowski, J.M.; Weiss, R.A. Successful treatment of depressed,distensible acne scars using autologous fibroblasts: A multi-site, prospective, double blind, placebo-controlled clinical trial. Dermatol. Surg. 2013, 39, 1226\u20131236.<\/li>
      10. Eca, L.P.; Pinto, D.G.; de Pinho, A.M.; Mazzetti, M.P.; Odo, M.E. Autologous fibroblast culture in the repair of aging skin. Dermatol. Surg. 2012, 38, 180\u2013184.<\/li>
      11. Zhang, X.; Deng, Z.; Wang, H.; Yang, Z.; Guo, W.; Li, Y.; Ma, D.; Yu, C.; Zhang, Y.; Jin, Y.Expansion and delivery of human fibroblasts on micronized acellular dermal matrix for skin regeneration. Biomaterials 2009, 30, 2666\u20132674.<\/li>
      12. Boss WK Jr, Usal H, Fodor PB, Chernoff G. Autologous cultured fibroblasts: a protein repair system. Ann Plast Surg 2000 May;44:536\u201342.<\/li>
      13. Robert A. Weiss; Margaret A. Weiss; Karen L. Beasley; Girish Munavalli. Autologous cultured fibroblast injection for facial contour deformities: a prospective, placebo-controlled, Phase III clinical trial, 2007 Dermatol Surg 2007;33:263\u2013268.<\/li>
      14. 2. Wong T, McGrath JA, Navsaria H. The role of fibroblasts in tissue engineering and regeneration. Br J Dermatol 2007; 156:1149-1155.<\/li>
      15. Solakoglu S, Tiryaki T, Ciloglu SE. The effect of cultured autologous fibroblasts on longevity of cross-linked hyaluronic acid used as a filler. Aesthetic Surg J 2008; 28: 412-416.<\/li>
      16. Nilforoushzadeh MA, Siadat AH, Arianrad M, Moulavi F, Baradaran EH, Esfahani MHN. Soft tissue augmentation by autologous cultured fibroblasts transplantation for treatment of wrinkles and scars: a case series of 20 patients. J Res Med Sci 2010; 15: 167-171.<\/li>
      17. E\u00e7a LP, Pinto DG, De Pinho AMS, Mazzetti MPV, Odo MEY. Autologous fibroblast culture in the repair of aging skin. Dermatol Surg 2012; 38: 180-184.<\/li>
      18. Bassetto F, Turra G, Salmaso R, Lancerotto, Del Vecchio DA. Autologous injectable dermis: a clinical and histological study. Plast Reconstr Surg 2013; 131: 589-596<\/li>
      19. Ferguson PC, Boynton EL, Wunder JS, Hill RP, O\u2019Sullivan B, Sandhu JS, Bell RS. Intradermal injection of autologous dermal fibroblasts improves wound healing in irradiated skin. J Surg Res 1999; 85: 331-338.<\/li>
      20. Karchilaki I, Topakas G, Castana O, Sotiriou P, Michelakis D, Giokas CS. The use of cultured autologous fibroblasts in burn wounds healing process. Burns 2007; 33: 791-792.<\/li>
      21. Kim JE, Lee OS, Choi J, Son SW, Oh CH. The efficacy of stereoimage optical topometry to evaluate depressed acne scar treatment using cultured autologous fibroblast injection. Dermatol Surg. 2011; 37:1304-13.<\/li>
      22. Mc Guire MK, Scheyer ET: A randomized, double-blind, placebo controlled study to determine the safety and efficacy of cultured and expanded autologous fibroblast injections for the treatment of interdental papillary insufficiency associated with the papilla priming procedure. J Periodontol 2007;78:4-17.<\/li>
      23. Nolte SV, Xu W, Rennakampff HO, Rodemann HP: Diversity of fibroblasts a review on implications for skin tissue engineering. Cells Tissue Organs 2008;187:165-76.<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

        Otolog Fibroblast H\u00fccre Tedavisi FIBROCELL\u00ae, ki\u015finin kendi dokusundan elde edilen fibroblast h\u00fccrelerinin, y\u00fcksek teknolojiye sahip laboratuvar ortam\u0131nda, biyom\u00fchendislik teknikleri ile \u00e7o\u011falt\u0131larak ki\u015finin ihtiya\u00e7 duydu\u011fu b\u00f6lgeye enjekte edilmesine dayanan otolog bir…<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-25","page","type-page","status-publish"],"lang":"tr","translations":{"tr":25,"en":454},"pll_sync_post":[],"_links":{"self":[{"href":"https:\/\/www.dokubiyoteknoloji.com\/index.php?rest_route=\/wp\/v2\/pages\/25","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dokubiyoteknoloji.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.dokubiyoteknoloji.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.dokubiyoteknoloji.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.dokubiyoteknoloji.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=25"}],"version-history":[{"count":22,"href":"https:\/\/www.dokubiyoteknoloji.com\/index.php?rest_route=\/wp\/v2\/pages\/25\/revisions"}],"predecessor-version":[{"id":412,"href":"https:\/\/www.dokubiyoteknoloji.com\/index.php?rest_route=\/wp\/v2\/pages\/25\/revisions\/412"}],"wp:attachment":[{"href":"https:\/\/www.dokubiyoteknoloji.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=25"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}