{"id":33,"date":"2024-02-21T14:35:33","date_gmt":"2024-02-21T14:35:33","guid":{"rendered":"http:\/\/www.dokubiyoteknoloji.com\/?page_id=33"},"modified":"2024-02-22T15:29:08","modified_gmt":"2024-02-22T15:29:08","slug":"kok-hucre","status":"publish","type":"page","link":"https:\/\/www.dokubiyoteknoloji.com\/?page_id=33","title":{"rendered":"K\u00f6k H\u00fccre"},"content":{"rendered":"\t\t
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K\u00f6k H\u00fccre<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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K\u00f6k h\u00fccreler belli doku karakteri ta\u015f\u0131mayan, uygun sinyal al\u0131n\u0131ncaya dek farkl\u0131la\u015fmam\u0131\u015f fenotiplerini koruyan, kendini yenileyebilme ve \u00e7o\u011falma \u00f6zelliklerine sahip h\u00fccreler olarak tan\u0131mlanmaktad\u0131r.<\/p>

\u0130nsano\u011flu varolu\u015fundan bu yana\u00a0 en b\u00fcy\u00fck hedeflerinden biri hastal\u0131klara \u00e7\u00f6z\u00fcm bulmak ve ya\u015fam s\u00fcresini uzatmak olmu\u015ftur. Pek \u00e7ok farkl\u0131 bitkiden elde edilen kar\u0131\u015f\u0131m\u0131n binlerce y\u0131l \u00f6nce tedavide kullan\u0131ld\u0131\u011f\u0131na dair bilgiler mevcuttur. M.\u00d6. 1534 y\u0131l\u0131na ait oldu\u011fu d\u00fc\u015f\u00fcn\u00fclen bir papir\u00fcste \u00e7e\u015fitli hastal\u0131klar\u0131n ve tedavilerin anlat\u0131ld\u0131\u011f\u0131 bilinmektedir. \u0130nsano\u011flunun bilin\u00e7 alt\u0131ndaki \u00f6l\u00fcms\u00fczl\u00fc\u011fe ula\u015fma iste\u011fi bug\u00fcne kadar t\u0131p biliminin itici g\u00fcc\u00fc olmu\u015ftur.<\/p>

\u00d6zellikle son 20-30 y\u0131ld\u0131r t\u00fcm d\u00fcnyada doku m\u00fchendisli\u011fi b\u00fcy\u00fck bir h\u0131zla ilerlemi\u015f ve gelinen noktada laboratuvar ortam\u0131nda insan k\u00f6k h\u00fccrelerinden dokular ve hatta 3 boyutlu organlar \u00fcretilebilme noktas\u0131na gelmi\u015ftir. \u0130nsan\u0131n kendi h\u00fccresinin al\u0131n\u0131p, yine kendisine uygulanmak \u00fczere (otolog), \u00a0h\u00fccre, doku veya organ \u00fcretilmesi; ila\u00e7 end\u00fcstrisinin yetersiz kald\u0131\u011f\u0131 pek \u00e7ok hastal\u0131\u011f\u0131 tedavi edebilmekte ve hastay\u0131 hayata ba\u011flamaktad\u0131r.<\/p>

Kendini yenileme ve farkl\u0131 h\u00fccrelere d\u00f6n\u00fc\u015febilme yetene\u011fine sahip k\u00f6k h\u00fccreler b\u00f6l\u00fcnme ve farkl\u0131la\u015fma \u00f6zelliklerine g\u00f6re 3 \u00e7e\u015fide ayr\u0131l\u0131rlar.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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1. TOT\u0130POTENT K\u00d6K H\u00dcCRELER\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tBildi\u011fimiz gibi memeliler i\u00e7in hayat zigot ad\u0131 verilen (spermin yumurtay\u0131 d\u00f6llemesi) tek h\u00fccreden ba\u015flar. Bu h\u00fccre totipotent bir h\u00fccredir ve yeti\u015fkin bir organizman\u0131n meydana gelmesi i\u00e7in gereksinim duyulan b\u00fct\u00fcn fonksiyonlar\u0131 ta\u015f\u0131maktad\u0131r. Bir totipotent h\u00fccre tek ba\u015f\u0131na bir canl\u0131y\u0131 olu\u015fturabilir. Bu \u00f6zelli\u011fini d\u00f6llenmeden sonraki 4 g\u00fcn boyunca s\u00fcrd\u00fcr\u00fcr. Totipotent h\u00fccreler, etik nedenler sebebiyle insan tedavisinde kullan\u0131lmamaktad\u0131r.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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2. PLUR\u0130POTENT K\u00d6K H\u00dcCRELER<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Embriyonik k\u00f6k h\u00fccre denilince blastosistin i\u00e7 h\u00fccre kitlesinden elde edilen pluripotent \u00f6zellikteki h\u00fccreler kastedilmektedir. Bu h\u00fccreler \u00fc\u00e7 embriyonik germ tabakas\u0131na farkl\u0131la\u015fma yetene\u011fine sahiptirler. \u00dc\u00e7 germ tabakas\u0131 bir yeti\u015fkindeki 220\u2019den fazla h\u00fccre tipini olu\u015fturur. Baz\u0131 farkl\u0131la\u015fm\u0131\u015f pluripotent h\u00fccreler, yeti\u015fkinlerde multipotent h\u00fccreler (\u00f6rne\u011fin kemik ili\u011finde) olarak bulunabilirler ancak bu h\u00fccrelerin farkl\u0131la\u015fma yetenekleri s\u0131n\u0131rl\u0131d\u0131r. S\u0131n\u0131rs\u0131z olarak kendilerini yenileyebilmeleri ve plastisite (farkl\u0131 h\u00fccre tiplerine d\u00f6n\u00fc\u015febilme) yetenekleri sebebiyle rejenatif t\u0131p\u2019\u0131n en \u00f6nem verdi\u011fi konulardan biri embriyonik k\u00f6k h\u00fccre ara\u015ft\u0131rmalar\u0131d\u0131r.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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3. MULT\u0130POTENT K\u00d6K H\u00dcCRELER (K\u00d6K H\u00dcCRE TEDAV\u0130S\u0130NDE KULLANILAN H\u00dcCRE)\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Yeti\u015fkin k\u00f6k h\u00fccreler, daha \u00e7ok nereden elde edildiyse o organa veya dokuya d\u00f6n\u00fc\u015febilme yetene\u011findedirler ve bunlar multipotent k\u00f6k h\u00fccreler olarak adland\u0131r\u0131l\u0131rlar. Multipotent k\u00f6k h\u00fccreler; \u00f6len ya da hasar g\u00f6ren h\u00fccreleri yenileme \u00f6zelli\u011fine sahip yeti\u015fkinlerde farkl\u0131la\u015fm\u0131\u015f dokularda bulunan farkl\u0131la\u015fmam\u0131\u015f h\u00fccrelerdir. Somatik k\u00f6k h\u00fccreler olarak da adland\u0131r\u0131l\u0131rlar. Kemik ili\u011fi, kas, g\u00f6z, sinir, karaci\u011fer ve deri gibi dokularda bulunurlar. B\u00f6l\u00fcnebilme ve kendilerini yenileyebilme \u00f6zellikleri vard\u0131r. Yeti\u015fkinde her organ ve dokuda ayn\u0131 say\u0131 ve potansiyelde k\u00f6k h\u00fccrelere rastlanmaz. \u00d6rne\u011fin, beyinde bu h\u00fccreler olduk\u00e7a az say\u0131da bulunmaktad\u0131r. Bu nedenle beyin hasarlar\u0131nda bir kemik veya doku gibi organ yenilenmesi olmaz, hasar genellikle kal\u0131c\u0131d\u0131r ve ciddi sonu\u00e7lar do\u011furur. Multipotent k\u00f6k h\u00fccreler, tedavi alan\u0131nda kullan\u0131lan k\u00f6k h\u00fccre grubunu olu\u015fturmaktad\u0131r.<\/p>

  1. Hematopoietik k\u00f6k h\u00fccreler (HSC):<\/strong>\u00a0Hematopoietik k\u00f6k h\u00fccreler t\u00fcm kan h\u00fccrelerinin \u00f6nc\u00fcleridir. Hematopoietik k\u00f6k h\u00fccreler t\u00fcm kan h\u00fccrelerinin \u00f6nc\u00fcleridir. Myeloid h\u00fccreler (monositler, makrofajlar, bazofiller, eosinofiller, eritrositler, megakaryositler\/plateletler ve baz\u0131 dendritik h\u00fccreler), ve lenfositler (T-h\u00fccreleri, B h\u00fccreleri, NK-h\u00fccreler) hematopoietik h\u00fccrelerin farkl\u0131la\u015fmas\u0131yla olu\u015fmu\u015f terminal h\u00fccrelerdir. Hematopoietik k\u00f6k h\u00fccreler yeti\u015fkinlerde, uyluk, kal\u00e7a, g\u00f6\u011f\u00fcs, kaburga ve di\u011fer kemiklerde kemik ili\u011finde bulunurlar. H\u00fccreler kal\u00e7a kemi\u011finden direkt \u015f\u0131r\u0131nga ile al\u0131nabilece\u011fi gibi, baz\u0131 ila\u00e7lar yard\u0131m\u0131yla (sitokin) kandan da elde edilebilir. Bug\u00fcn l\u00f6semi hastalar\u0131nda s\u0131kl\u0131kla kemik ili\u011fi nakli olarak bahsedilen k\u00f6k h\u00fccreler hematopoietik k\u00f6k h\u00fccrelerdir.<\/li>
  2. Mezen\u015fimal K\u00f6k H\u00fccreler (MSC):<\/strong>\u00a0 Mezen\u015fimal k\u00f6k h\u00fccreler , ya\u011f dokuda, kemik ili\u011finde, kordon kan\u0131nda bulunan, kendilerini yenileme, farkl\u0131la\u015fma ve \u00f6zellikle doku onar\u0131m kapasiteleri olduk\u00e7a y\u00fcksek olan k\u00f6k h\u00fccrelerdir.<\/li>
  3. Adipoz Doku k\u00f6k H\u00fccreleri (SVF):<\/strong>\u00a0 Adipoz doku k\u00f6k h\u00fccreleri (ASC); insan ya\u011f dokusunun lipoaspirat y\u00f6ntemi ile al\u0131nmas\u0131 ve laboratuvar ortam\u0131nda manuel \u00f6zel tekniklerle izole edilmisiyle elde edilebilmektedir. Pek \u00e7ok \u00f6zellikleriyle kemik ili\u011finde bulunan mezen\u015fimal k\u00f6k h\u00fccrelere (MSC) benzerler. Kemik ili\u011fine k\u0131yasla, ya\u011f dokunun al\u0131nmas\u0131 daha az ac\u0131 vericidir. Laboratuvar ortam\u0131nda, insan adipoz kaynakl\u0131 k\u00f6k h\u00fccrelerin (SVF) kemik, k\u0131k\u0131rdak, ya\u011f ve kas h\u00fccrelerine farkl\u0131la\u015fabildi\u011fi g\u00f6sterilmi\u015ftir. Ya\u011f kaynakl\u0131 k\u00f6k h\u00fccrelerin pek \u00e7ok farkl\u0131 hastal\u0131kta kullan\u0131labildi\u011fi ve ba\u015far\u0131l\u0131 sonu\u00e7lar\u0131n al\u0131nabildi\u011fi rapor edilmi\u015ftir. Ayr\u0131nt\u0131l\u0131 bilgi i\u00e7in\u00a0FATCELL\u2019i<\/u>\u00a0<\/a>inceleyiniz.<\/li><\/ol>

    *Mezen\u015fimal ve ya\u011f kaynakl\u0131 k\u00f6k h\u00fccreler(SVF), h\u00fccresel tedaviler alan\u0131nda en s\u0131k kullan\u0131lanlard\u0131r.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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    Kaynaklar<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    • http:\/\/stemcells.nih.gov\/<\/li>
    • http:\/\/www.news.wisc.edu\/packages\/stemcells\/<\/li>
    • http:\/\/stemcells.nih.gov\/info\/basics<\/li>
    • http:\/\/ink.primate.wisc.edu\/~thomson<\/li>
    • http:\/\/www.stemcellresearchfoundation.org\/<\/li>
    • http:\/\/www.stemcells.wisc.edu\/<\/li>
    • www.wikipedia.org<\/li>
    • http:\/\/www.stemcellthera.com\/<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

      K\u00f6k h\u00fccreler belli doku karakteri ta\u015f\u0131mayan, uygun sinyal al\u0131n\u0131ncaya dek farkl\u0131la\u015fmam\u0131\u015f fenotiplerini koruyan, kendini yenileyebilme ve \u00e7o\u011falma \u00f6zelliklerine sahip h\u00fccreler olarak tan\u0131mlanmaktad\u0131r. \u0130nsano\u011flu varolu\u015fundan bu yana\u00a0 en b\u00fcy\u00fck hedeflerinden biri…<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-33","page","type-page","status-publish"],"lang":"tr","translations":{"tr":33,"en":469},"pll_sync_post":[],"_links":{"self":[{"href":"https:\/\/www.dokubiyoteknoloji.com\/index.php?rest_route=\/wp\/v2\/pages\/33","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dokubiyoteknoloji.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.dokubiyoteknoloji.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.dokubiyoteknoloji.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.dokubiyoteknoloji.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=33"}],"version-history":[{"count":22,"href":"https:\/\/www.dokubiyoteknoloji.com\/index.php?rest_route=\/wp\/v2\/pages\/33\/revisions"}],"predecessor-version":[{"id":294,"href":"https:\/\/www.dokubiyoteknoloji.com\/index.php?rest_route=\/wp\/v2\/pages\/33\/revisions\/294"}],"wp:attachment":[{"href":"https:\/\/www.dokubiyoteknoloji.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=33"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}